Brian Zabel, Ph.D.

Brian Zabel, Ph.D.

Dr. Zabel is a Senior Research Scientist at the Palo Alto Veterans Institute for Research.  Dr. Zabel received B.S. degrees in Biology and Mathematics from the Massachusetts Institute of Technology in 1997 and a Ph.D. in Immunology from Stanford University in 2004. His Ph.D. thesis and postdoctoral work focused on the identification and characterization of novel white blood cell attractant chemerin and its receptors in homeostasis and inflammatory disease.

His laboratory, which is funded by the National Institutes of Health, Department of Defense, and the Pulmonary Fibrosis Foundation, has recently focused on understanding the potential protective role of white blood cells in experimental models of pulmonary fibrosis. These studies may lead to innovative approaches to use the body’s own anti-fibrotic white blood cells to improve interstitial lung disease.  In other recent work, his laboratory identified a pathogenic role for chemerin receptor CMKLR1 in demyelinating disease, and discovered a new small molecule drug that can prevent clinical signs of experimental autoimmune CNS inflammation in mice.  This proof-of-concept work may lead to novel treatments for multiple sclerosis in the clinic.  Dr. Zabel holds seven patents, has published more than 40 peer-reviewed research papers, review articles, and book chapters, and is a recipient of the Hugh McDevitt Prize (Stanford University 2004) and the Albert Rose Established Investigator Award (Pulmonary Fibrosis Foundation 2014). He is Chair of the Institutional Animal Care and Use Committee at the VA Palo Alto Health Care System.

Learn More: zabellab.pavir.org