Featured Projects

The range of our research activities is broad and includes both clinical and basic bench research.

Skeletal Health in the Lower Limbs Following Spinal Cord Injury

Individuals with complete spinal cord injuries (SCIs) are at high risk for bone fractures in their legs because of the loss of bone mass which generally occurs after injury. Fractures after SCI are costly to treat and often lead to additional medical complications. In order to reduce the incidence of fractures, more effective rehabilitation strategies are needed to prevent bone loss after SCI.
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In addition to our featured projects, you may wish to take a look at the complete list of our currently active funded projects.

Many of the titles are written for academically trained experts, but nonetheless, scanning the titles will communicate the breadth and depth of our research activities.  All of PAVIR administered research is conducted at the VA Palo Alto Health Care System.

See Complete List of Research Projects

  • Cell Processing High Density Lipoproteins
  • Effects of Apolipoprotein A-I Mimetics on Atherosclerosis in Rodent Models
  • A Multimodal Evaluation of the Comparative Efficacy of Yoga versus a Patient-Centered Support Group for Treating Chronic Pain in Gulf War Illness
  • A Test of the Efficacy of Compassion Cultivation Training for Veterans with PTSD
  • A Randomized Controlled Trial of Rivaroxaban for the Prevention of Major Cardiovascular Events in Patients with Coronary or Peripheral Artery Disease (COMPASS – Cardiovascular OutcoMes for People using Anticoagulation StrategieS)
  • Vaccination and Infection: Indicators of Immunological Health and Responsiveness
  • Non-invasive Mass Cytometric Monitoring of Tissue Specific Immune Responses in Man
  • Clonal Analysis of Tissue Specific Immune Response in Man
  • Intestinal Lymphocyte Trafficking
  • T Cell Responses to H1N1 and a Longitudinal Study of Seasonal Flu Vaccination
  • Novel Mucosa-Homing Dendritic Cell: Development, Trafficking and Function
  • Chemerin in Tumor Immunity and Surveillance
  • The Benefit and Burden of Electronic Reminders for Optimizing Patient Care
  • Tendon-Bone Composite Tissue Engineering in a Rabbit Model
  • A Phase 4, Multicenter, Open Label Study to Investigate the Efficacy and Safety of an All Oral Combination Sofosbuvir + Ribavirin in Genotype 2 HCV-infected U.S. Veterans with Cirrhosis
  • Chondrogenesis in Situ
  • Molecular Mechanisms of Mammalian SIRT6 Function
  • Inflammasome Activation in Complex Regional Pain Syndrome
  • The In Silico Genetic Analysis of Opioid Adaptations
  • Targeting Epigenetic Mechanisms in Pain due to Trauma and Traumatic Brain Injury (TBI)
  • Implementation of an Evidence-Based PTSD Treatment in Public Sector Settings
  • Effects of Early Acute Care on Autonomic Outcomes in SCI: Beside to Bench and Back
  • Restoration of Bladder and Bowel Function Using Electrical Stimulation and Block after Spinal Cord Injury
  • Telmisartan in the Management of Abdominal Aortic Aneurysm (TEDY)
  • Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA^3CT)
  • The Neurobiology of Psychotherapy: Emotional Reactivity and Regulation in PTSD
  • Emotion Regulation in Anxiety & Depression: A Novel Neurobehavioral Intervention
  • A Combined Training Program for Veterans with Amnestic Mild Cognitive Impairment
  • Fame II Trial, Fractional Flow Reserve-Guided Percutaneous Coronary Intervention plus Optimal Medical Treatment versus Optimal Medical Treatment Alone in Patients with Stable Coronary Artery Disease
  • A Prospective, Single Blind, Randomized Controlled Study to Evaluate the Safety and Effectiveness of the Tryton Side Branch Stent used in Conjunction with a Drug-Eluting Stent Compared to Side Branch Balloon Angioplasty in Conjunction with a Drug-Eluting Stent in the Treatment of de novo Bifurcation Lesions Involving the Main Branch and Side Branch within the Native Coronary Circulation
  • Can cONTrast injection better approximate FFR compAred to pure reSTing physiology?  (CONTRAST) Trial
  • Medtronic CoreValve U.S. Pivotal Trial
  • Medtronic CoreValve Continued Access Study
  • Medtronic CoreValve U.S. Expanded Use Study
  • Medtronic CoreValve U.S. SURTAVI Study
  • Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) 3 Trial
  • REPRISE III: Repositionable Percutaneous Replacement of Stenotic Aortic Valve through Implantation of Lotus Valve System – Randomized Clinical Evaluation
  • Development and Implementation of Patient-Centered Guidelines
  • Vaccine Induced Immunity in the Young and Aged – Immune Senescence
  • T Cell Responses to Varicella Zoster Virus after Vaccination and Viral Escape
  • Influence of CMV Infection on Vaccine Responses
  • Influence of Age on CD4 T Memory Cells
  • microRNA Regulation of T Cell Senescence
  • Reducing Late-Life Anxiety and Improving Function with Self-Directed Relaxation
  • Viral Gastroenteritis: Basis of Protection and Virulence
  • B Cell Immunity to Influenza
  • Vaccination and Infection: Indicators of Immunological Health and Responsiveness
  • B and T Cell Responses to Rotavirus Infection and Vaccination in Indian Infants
  • Mucosal and Systemic Immune Responses to Influenza Virus
  • Stanford Cooperative Research Center for Novel, Alternative Model Systems for Enteric Diseases
  • Role of Peripheral Dendritic Cells in Central and Oral Tolerance
  • The Role of Thymic Homing Dendritic Cells in Oral Tolerance
  • Defense and Veterans Brain Injury Center (DVBIC)
  • Role of Long-Range Chromatin Interactions in Genetic Disease
  • Quantifying the Burden of Norovirus Gastroenteritis
  • Evaluation of the GeneWeave vivoDx™ MRSA Screen Assay Protocol TP012
  • The T.Jacket PTSD Study: Analyzing the Impact of Wearing T.Jacket in Patients with Posttraumatic Stress Disorder (PTSD)
  • Treatment of Social Competence in Military Veterans & Civilians with Traumatic Brain Injury
  • Matrix-mediated Endothelial Differentiation of Induced Pluripotent Stem Cells
  • The Role of Oxidative Stress and Inflammation on Synaptic Functions After Exposure to Space Radiation
  • Towards an Unbiased Estimate of the Effectiveness of Alcoholics Anonymous
  • Early Quantitative Characterization of Reciprocal Social Behavior
  • Improving the Early Detection of Schizophrenia and Outcomes with a Novel Method of Precisely Measuring Subtansia Nigra Activity
  • Multi-Center Randomized Trial on the Detection, Diagnosis and Therapy of Pre-and Early Gastrointestinal Cancer using High Definition Dual Force Focus Narrow Band Imaging Endoscope
  • Mechanisms of Neuroinflammation after Fracture
  • Successful Strategies for Activity and Wellness after Spinal Cord Injury
  • Modulation of Inflammation by a Droplet-Associated Protein.
  • A Clinical Outcomes Study to Compare the Effect of Fluticasone Furoate/ Vilanterol Inhalation Powder 100/25mcg with Placebo on Survival in Subjects with Moderate Chronic Obstructive Pulmonary Disease (COPD) and a History of or at Increased Risk for Cardiovascular Disease
  • A 52-Week, Double-Blind, Randomized, Placebo Controlled Parallel Group Study to Evaluate the Effect of Roflumilast 500 on Exacerbation Rate in Subjects with Chronic Obstructive Pulmonary Disease (COPD) Treated with a Fixed Dose Combination of Long-Acting Beta Agonist and Inhaled Corticosteroid (LABA/ICS)
  • A Randomised, Double-blind, Chronic Dosing (56-week) Placebo-controlled, Parallel Group, Multicentre, Phase III Study to Evaluate the Efficacy and Safety of 2 Doses of Benralizumab (MEDI-563) in Patients with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) with a History of COPD Exacerbations (GALATHEA)
  • Neural Dimensions of Threat Reactivity and Regulation for Understanding Anxiety
  • Androgen-Estrogen Balance in CVD Risk
  • Metabolic Syndrome as Women Undergo Menopausal Transition: A Multi-Ethnic Study
  • Caring Letters for Military Suicide Prevention: A Randomized Controlled Trial
  • Cross-talk Between Coagulation, Inflammation, and Immunity
  • Rapid Molecular Triaging of Bladder Cancer using RT-PCR
  • A Behavioral Sleep Intervention for Suicidal Behaviors in Military Veterans: A Randomized Controlled Study
  • Targeting PCSK9 Transcription to Combat Hypercholesterolemia by Berberine
  • Novel Small Molecule TGF-beta Agonist for the Treatment of Parkinson’s Disease
  • Regional Anesthesia Educational Center
  • Regional Anesthesia/Acute Pain Management Program 
  • Treating Intractable Post-Amputation Phantom Limb Pain with Ambulatory Continuous Peripheral Nerve Blocks
  • Retained Organic Solutes and Clinical Outcomes in Hemodialysis
  • Removal of Protein-Bound Solutes by Hemodialysis
  • Dietary and Microbial Reprogramming of Intestinal Microbiota-Produced Metabolites.
  • Thrombomodulin Receptors on Immune Cells
  • Cell Characterization and Imaging for Regenerative Therapies in Ischemic Disease
  • MRI Assesment of Coronary Function in Women and Men Without Obstructive CAD
  • Association of Low Dose Radiation from Cardiac Computed Tomography with DNA Damage and Cell Death in Immune Cells
  • Proteomics of Inflammation, Immunity, and Pulmonary Arterial Hypertension
  • An Autoimmune Basis for Pulmonary Hypertension
  • A Critical Role for the Microvasculature in Airway Transplantation
  • Elafin Therapy for Lung Diseases
  • Leukotriene B4-mediated Pulmonary Arterial Hypertension
  • Developing Methods for Brain Stimulation Enhanced Fear Reversal in PTSD
  • Impact of Social-Networking on Dose and Effects of Cancer Survivorship Trials
  • ENaC Regulation by Cell Surface Associated SGK1
  • Cancer Stem-Cell Research with Patient Reported Outcomes (CanSR-PRO)
  • In-Reach for Successful Aging through Education (i-SAGE)
  • ACE Inhibition and Cardiac Allograft Vasculopathy
  • Left Atrial Pressure Monitoring to Optimize Heart Failure Therapy Study (LAPTOP-HF)
  • Prevention of Cardiac Allograft Vasculopathy Using Rituximab (Rituxan) Therapy in Cardiac Transplantation 
  • A Multicenter, Randomized, Double-blind, Placebocontrolled Phase IIIb Study to Evaluate the Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in Acute Heart Failure Patients
  • Cooperative Group Clinical Trials Program-ECOG
  • Notch Signaling and Satellite Cell Activation
  • Wnt Signaling in Muscle Stem Cell Aging
  • The Function and Regulation of Pax3 in Muscle Stem Cells
  • Role of Systemic PAI-1 (SERPINE1) in Aging Skeletal Muscle
  • Molecular Regulation of Stem Cell Potency
  • A New Muscle-Brain Axis Underlying the Cognitive Benefits of Physical Activity
  • Antibiotics and Human Microbial Community Dynamics
  • Hyposalivation and the Human Oral Microbiome
  • Predicting Resilience in the Human Microbiome
  • Pathogenesis and Prediction of Future Rheumatoid Arthritis
  • Novel Biomarkers and Prediction Models for Rheumatoid Arthritis
  • Randomized, Controlled Trial of CBT Training for PTSD Providers
  • The PTSD Practitioner Registry: An Innovative Tracking, Dissemination, and Support Tool for Providers in Military and Non-Military Settings
  • Improving Adrenergic Signaling in the Treatment of Cognitive Dysfunction in Down Syndrome
  • Improving Adrenergic Signaling in the Treatment of Cognitive Dysfunction in Down Syndrome
  • Effects of Chronic Intermittent Hypoxemia on Cognitive Function in Down Syndrome
  • Improving ß2 Adrenergic Signaling in Alzheimer’s Disease
  • Phase 3 Prospective, Randomized, Blinded and Controlled Investigation of Hepasphere/Quadrasphere Microspheres for Delivery of Doxorubicin for the Treatment of Hepatocellular Cancer
  • T Cell Response to Myelin Proteolipid Protein
  • Aquaporin-4 (AQP4)-Specific T Cells in CNS Autoimmunity
  • Citrullinated Antigens Bridge Innate and Adaptive Immunity in RA
  • A Randomized, Head to Head Single Blind Study to Compare the Efficacy and Safety of Subcutaneous Abatacept versus Subcutaneous Adalimumab both with Background Methotrexate in Biologic Naive Subjects with Rheumatoid Arthritis
  • Phase IIB, Randomized, Multi-Center, Double-Blind, Dose-Ranging, Placebo/Active Controlled Stud to Evaluate the Efficacy and Safety of BMS-945429 Subcutaneous Injection with or Without Methotrexate in Subjects with Moderate to Severe Rheumatoid Arthritis with Inadequate Response to Methotrexate
  • Anti-Citrullinated Protein Antibodies as Biomarkers of Cardiovascular Risk in RA
  • First Longitudinal Study of Missed Treatment Opportunities using DOD and VA Data
  • Longitudinal Study of Post-Deployment CAM Pain Management Using DoD and VA Data
  • Development and Initial Testing of Performance Measures for Addiction Medicine
  • 2/2 A Randomized Trial of Internet-Based Interventions for Bipolar Disorder
  • A Randomized, Double-Blind, Placebo Controlled, Flexible-dose, Parallel-Group Study of Lurasidone Adjunctive to Lithium or Divalproex for the Prevention of Recurrence in Subjects with Bipolar Disorder (D1050296)
  • A Multicenter, Open-Label, Flexible-Dose Extension Study of Lurasidone Adjunctive to Lithium or Divalproex in Subjects with Bipolar I Disorder
  • A Prospective, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Safety and Efficacy Study of Oral ELND005 as an Adjunctive Maintenance Treatment in Patients with Bipolar I Disorder
  • Cognitive Decline in Chronic Renal Insufficiency – Extension study
  • MicroRNA Regulation of Nicotine Accelerated AAAs
  • DNA Variants and AAA Disease
  • Rates of Stroke and Systemic Embolism in Patients Contraindicated for Oral Anticoagulants with non-valvular Atrial Fibrillation
  • Comparative Effectiveness and Safety of Atrial Fibrillation Therapies in Chronic Kidney Disease
  • Global Registry on Long-Term Oral Antithrombotic TReatment In PAtients with Atrial Fibrillation (“GLORIA-AF”)
  • ORBIT-AF II: Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II
  • A Big Data Approach to Determine Treatment Thresholds of Atrial Fibrillation Burden and Duration for Prevention of Ischemic Stroke
  • Translating, Understanding, and Learning to Prevent Incontinence
  • Can a Canine Companion Modify Cardiac Autonomic Reactivity and Tone in PTSD
  • The Longitudinal Unbiased Immusine Profiling in Early Stage Alzheimer’s Disease
  • Circulatory Rejuvenating Factors for the Brain
  • A New Muscle-Brain Axis Underlying the Cognitive Benefits of Physical Activity
  • Optogenetic Interrogation of Sleep Circuits During Aging
  • e-CAeSAR: Evaluation of a Cognitively Adaptive e-treatment in Schizophrenia-diagnosed Adults: A Remediation-based Approach
  • A Multicenter, Open-label Study to Assess Hospitalization Rates in Adult Subjects with Schizophrenia Treated Prospectively for 6 Months with Aripiprazole IM Depot Compared with 6-month Retrospective Treatment with Oral Antipsychotics in a Naturalistic Community Setting in the United States
  • Alzheimer’s Disease Neuroimaging Initiative 2 (ADNI-2)
  • Effects of Traumatic Brain Injury (TBI) and Post Traumatic Stress Disorder (PTSD) on Alzheimers Disease (AD) in Veterans Using Imaging and Bio Markers in the AD Neuroimaging Initiative (ADNI) 
  • Treatments for Insomnia: Moderators, Mediators, and Quality of Life
  • Anti-Amyloid Treatment in Asymptomatic Alzheimers Disease (A4) Study
  • Anti-Amyloid Treatment in Asymptomatic Alzheimers Disease (A4) Study
  • Molecular and Functional Characterization of Chemerin Receptors
  • Role of Chemerin Peptides in Psoriasis
  • Targeting Chmerin Receptor CMKLR1 in Multiple Sclerosis
  • Role of Chemerin and its Receptors in TGF-best-induced Experimental Pulmonary Fibrosis
  • Hybridoma Monoclonal Antibody Generation
  • Targeting the Nociceptin/Orphanin FQ Receptor for Scleroderma Therapy
  • The Role of Antimicrobial Chemerin in Skin Biology
  • Ultrashort (msec) Light Exposure as a Countermeasure to Circadian Desynchrony
  • Open-Label Safety Study of a 24-Month 20mg Dose Regimen of Tasimelteon for the Treatment of  Non-24-Hour Sleep-Wake Disorder (N24HSWD) in Blind Individulas with no Light Perception
  • Endovascular Repair using the Talent Abdominal Stent Graft System in Abdominal Aortic Aneurysms (VITALITY)
  • Clinical Study to Evaluate the Safety and Effectiveness of the Zenith Branch Endovascular Graft-Iliac Bifurcation with the Zenith Connection Endovascular Covered Stent (aka PRESERVE)
  • Long-Term Cognitive Effects of Microembolization Associated with Carotid Stenting
  • The JET Registry – Jetstream Navitus™ System Endovascular Therapy Post-Market Registry
  • A Prospective, Single-Blind, Randomized, Phase III Study to Evaluate the Safety and Efficacy of Fibrin Sealant Grifols (FS Grifols) as an Adjunct to Hemostasis during Peripheral Vascular Surgery
  • A Multicenter, Open Label, Prospective, Non-Randomized Study of the INCRAFT™ Stent Graft System in Subjects with Abdominal Aortic Aneurysms
  • A Randomised, Double-Blind, Parallel Group, Multicentre Phase IIIb Study to Compare Ticagrelor with Clopidogrel Treatment on the Risk of Cardiovascular Death, Myocardial Infarction and Ischaemic Stroke in Patients with Established Peripheral Artery Disease (EUCLID – Examining Use of tiCagreLor In paD)
  • Neuroimaging Correlates of Memory Decline Following Carotid Interventions
  • A Phase 1 Multicenter, Open-Label, Dose-Escalation Study to Evaluate the Safety and Efficacy of Intramuscular Injection of Human Placenta-Derived Cells (PDA-002) in Subjects with Peripheral Arterial Disease and Diabetic Foot Ulcer
  • Prospective Multicenter Primary Below the Knee Bypass Evaluation with CryoVein® Cryopreserved Saphenous Vein Allograft in Patients with Critical Limb Ischemia
  • Randomized, Multicenter, Controlled Trial to Compare Best Endovascular versus Best Surgical Therapy in Patients with Critical Limb Ischemia
  • Zilver PTX V Post Market Study
  • A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose Range Finding Study to Evaluate the Efficacy and Safety of Intramuscular Injection of Human Placenta-Derived Cells (PDA-002) in Subjects Who Have Diabetic Foot Ulcer (DFU) with Peripheral Arterial Disease (PAD)

A few words regarding the research process.

Most studies are designed over a period of several months, and many project ideas are born based on many years of related work by the project director.  Once a research proposal is submitted to a potential funding source for their consideration, researchers usually have to wait for months to hear about the review result.  When a study is approved for funding, the study then undergoes internal review processes commensurate with the characteristics of a study.  For example, studies using dangerous research materials have to pass a safety review.  In all cases, the review is geared to include appropriate quality, safety, ethics, and cost/benefit assurances prior to engaging in the work.  We view this multi-step review process as quality assurance.  After all, much of our research is clinical research that includes the voluntary participation of Veterans – we agree that research with and for Veterans must follow strict guidelines.